Class I Phosphoinositide 3-Kinase PIK3CA/p110α and PIK3CB/p110β Isoforms in Endometrial Cancer
نویسندگان
چکیده
منابع مشابه
Oncogenic transformation induced by the p 110 , - , and - isoforms of class I phosphoinositide 3 - kinase
Class I phosphoinositide 3-kinase contains four isoforms of the catalytic subunit, p110 , , , and . At physiological levels of expression, the wild-type p110 isoform lacks oncogenic potential, but gain-of-function mutations and overexpression of p110 are correlated with oncogenicity. The p110 , , and isoforms induce transformation of cultured cells as wild-type proteins. This oncogenic potentia...
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Phosphoinositide 3-kinases (PI3Ks) participate in signal transduction cascades that can directly activate and sensitize nociceptors and enhance pain transmission. They also play essential roles in chemotaxis and immune cell infiltration leading to inflammation. We wished to determine which PI3K isoforms were involved in each of these processes. Lightly anesthetized rats (isoflurane) were inject...
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Although it is now well established that PI3K (phosphoinositide 3-kinase) is a key enzyme in several intracellular processes, there are still relatively few reports that precisely identify the specific isoforms of PI3K actually involved in such events. The lack of specific inhibitors has made it particularly difficult to address the physiological roles of some isoforms, such as the members of c...
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Class I phosphoinositide 3-kinases (PI3Ks) play a critical role in regulating chemoattractant-induced migration of neutrophils.1 However, Puri et al have demonstrated that PI3K activity in vascular endothelium also contributes to the accumulation of these cells in tissues, as evidenced by the reduced ability of PI3K-deficient blood vessels to support rolling adhesion of WT neutrophils in respon...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2018
ISSN: 1422-0067
DOI: 10.3390/ijms19123931